Purpose: This research aims to increase the level of usability and user experience website RSUD Dr. Tjitrowardojo Purworejo through improvements to the interface design and features website by prioritizing user needs and preferences using a User Centered Design (UCD) and testing approach usability System Usability Scale (SUS).Design/methodology/approach: The research was carried out using a quantitative approach through a questionnaire survey distributed to users website RSUD Dr. Tjitrowardojo Purworejo. The data from the survey results are then analyzed and the recommendation design is implemented in the form wireframe, mockup, and design guideline.Findings/result: Recommendation design results from redesign UI/UX significantly improves the acceptance aspect (Acceptability) and user satisfaction website Net Promoter Score (NPS). Thus the design recommendations result from the process redesign in this research can be implemented in website RSUD Dr. Tjitrowardojo Purworejo in the future because it can accurately answer user problems and their needs.Originality/value/state of the art: This research adapts the model User Centered Design (UCD) according to ISO 9241-210:2010, which has previously been used in various evaluations website hospital and website-website other. The process of identifying feature and appearance requirements website In this research, it was identified through the process of distributing user needs questionnaires and user feature display preference questionnaires.