Despite the presence of numerous efficacious bioactive compounds, the development of effective cancer therapies remains necessary. Thus, the exploitation of the medicinal potential of bioactive compounds in cancer management has become an urgent demand. Arctigenin (AG), a natural lignin derived from Arctium lappa , not only suppresses the proliferation of diverse cancerous cells, including those in the liver, stomach, lungs, and colon, but also modulates various antitumor, intracellular, antioxi