Inflammatory bowel disease (IBD) is a group of chronic conditions characterized by relapsing inflammation of gastrointestinal tract. Conventional treatments for IBD are confronted with various challenges including treatment failure, a therapeutic ceiling that restricts effectiveness and associated adverse effects. Present study employed Drosophila melanogaster as a model organism to investigate the protective effect of Holarrhena pubescens Wall. ex G. Don (Kutaj) Bark Extract (HpBE) against sodi