Transdermal patches are a non-Invasive a patient-friendly drug delivery System designed to deliver therapeutic Agents through the skin in a controlled Manner. Acne vulgaris is a common Dermatological disorder associated with Bacterial infection, inflammation, and Excessive sebum production. The present Study focuses on the formulation and Physicochemical evaluation of transdermal anti-acne patch incorporating Bioactive-rich Psidium guajava (guava) Leaf extract, known for its antimicrobial, Anti-