Abstract Thrombocytopenia is a common hematological disorder with diverse etiologies. This study aimed to identify potential biomarkers and to develop an interpretable diagnostic nomogram for the early recognition of hypo-productive thrombocytopenia. This retrospective study included 185 patients with thrombocytopenia who were admitted to the Department of Hematology at the Affiliated Suzhou Hospital of Nanjing Medical University between 2020 and 2025. Patients were categorized into hypo-product