Floating Microspheres meet all the requirements for a powerful drug carrier in the current scenario of delivering therapeutic agents to the target site, which requires for an effective drug delivery carrier that can only deliver the drug on the site of action in a sustained and controlled manner. Microspheres, which range in size from 1 to 1000 microns, are free-flowing powders made of biodegradable proteins or synthetic polymers. A well-thought-out controlled drug delivery system can improve th