The present study aimed to develop and characterize black seed oil-loaded microsponges for the topical management of vitiligo. Black seed oil (Nigella sativa oil), known for its antioxidant and antiinflammatory properties, was incorporated into microsponge formulations using the quasi-emulsion solvent diffusion method. Different formulations were prepared by varying polymer concentration and evaluated for production yield, particle size, entrapment efficiency, surface morphology, in vitro drug r