Efficacy and safety of stereotactic radiotherapy in patients with HER2-positive breast cancer brain metastases following intracranial oligoprogression

Tyrosine kinase inhibitors (TKIs) demonstrate clear therapeutic effects in patients with HER2−positive breast cancer complicated by brain metastases. However, the efficacy and safety of salvage stereotactic radiotherapy (SRT) for intracranial oligoprogression after TKI therapy remain unclear. This single-center retrospective cohort study aimed to evaluate the clinical value of SRT in this specific population, enrolling 40 HER2-positive breast cancer patients with brain metastases who received SR