ABSTRACT Melanoma progression is sustained by profound metabolic rewiring and immune suppression within the tumor microenvironment, where adipocyte‐derived lipid droplets (LDs) serve as key metabolic regulators. Here, we exploit this intrinsic biology by engineering resveratrol‐loaded LDs (RSV‐LDs) as natural, lipophilic nanocarriers to drive intracellular delivery and immunometabolic reprogramming. To achieve precise and localized administration, RSV‐LDs were integrated into soluble microneedle