Electro‐Pyroptosis Immunotherapy of Cancer via Endoplasmic Reticulum‐Mitochondria Crosstalk Evoked by Ultrasound‐Activated Wireless Electrostimulation

ABSTRACT Effectively inducing endoplasmic reticulum (ER) stress to initiate cell pyroptosis is promising to elevate cancer immunotherapy, as it avoids immune escape of tumor cells and insufficient differentiation of immune cells. However, it remains a major challenge due to the lack of effective ways to induce ER stress. Herein, we reported the conceptually new electro‐pyroptosis immunotherapy (EPI‐therapy) of cancer via ER‐mitochondria crosstalk by wireless electrostimulation ( w ES), enabled b