Eligibility Restrictiveness and Generalisability in Radiation Immunotherapy Trials for Head and Neck Squamous Cell Carcinoma: A Systematic Review of Trial Protocols

Introduction: Head and Neck Squamous Cell Carcinoma (HNSCC) commonly affect older patients who often have multiple co-morbidities. With the growing use of Radiation Immunotherapy (RT-ICI) combinations in head and neck malignancies, concerns have emerged regarding the representativeness of trial populations. Aim: The present study aimed to evaluate the prevalence and cumulative burden of restrictive eligibility criteria in contemporary Phase II-III RT-ICI trials. Materials and Methods: This syste