Leveraging dynamic serum uric acid trajectories for risk stratification in hospitalized HFpEF patients

Background Single-timepoint SUA measurement provides limited prognostic insight in acute heart failure with preserved ejection fraction (HFpEF). This study assessed whether dynamic in-hospital SUA trajectories (using admission and pre-discharge measurements) are more strongly associated with long-term outcomes than static single-timepoint measures. Methods The cohort consisted of 4,164 acute HFpEF patients, drawn from the China Heart Failure Center Registry. The primary outcome was a major adver