Homozygous pericentric inversion of chromosome 9 in a male with infertility

Pericentric inversion of chromosome 9 [inv(9)] is a common structural variant traditionally considered a benign heterochromatic polymorphism. However, its potential role in reproductive disorders remains controversial. We report a rare case of a 32-year-old male with primary infertility and homozygous inv(9)(p11q13), confirmed through high-resolution Giemsa-Trypsin-Giemsa (GTG) banding. While most literature focuses on heterozygous carriers, homozygous inv(9) cases are sporadic and poorly unders