BACKGROUND During the pathological advancement of chronic hepatitis B (CHB) toward cirrhosis and hepatocellular carcinoma, liver fibrosis acts as a pivotal transitional phase. Currently, non-invasive diagnostic techniques have become key substitutes for liver biopsy. However, the diagnostic efficacy of different indicators varies across populations, and the influence of factors such as gender, nutritional status, and liver function reserve remains unclear, necessitating further clarification. AI