Silent Immune Vulnerability and Serious Adverse Events Following Immunization
Tchame Claudric Roosvelt·Tchokfe Ndoula Shalom·Adrien Fapeingou Tounkara·Mengue Essindi Annie·Atangana Yene Roxanne Lucienne·Ewane Olivier
Background. From smallpox variolation practiced in imperial China in the 10th century to the messenger RNA vaccines deployed in 2020, vaccination ranks among the most effective public health interventions in the history of medicine. Nevertheless, the rare but clinically significant occurrence of serious adverse events following immunization (AEFI) remains a major challenge for contemporary pharmacovigilance. Identifying the individual determinants of susceptibility represents a leading scientifi