Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis

BACKGROUND Polytrauma is associated with the release of various biomarkers, including interleukin (IL)-6, a proinflammatory cytokine with prognostic value. AIM To evaluate the association between IL-6 measured within the first 24 hours of admission and the injury severity score (ISS) among adult polytrauma patients and to explore the link between early IL-6 levels and in-hospital mortality. METHODS We conducted a systematic review and meta-analysis of articles published between 2004 and 2024 in