A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer’s Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2)

Objective: ABRUPT2 was a prospective, randomized, multicenter trial to determine whether lactated Ringer’s + 5% albumin (Alb) reduces resuscitation requirements compared to lactated Ringer’s (LR) alone in major burns. Summary Background Data: The prospective, observational, multicenter ABRUPT study(1) found that initiation of albumin rapidly lowered fluid input and improved urine output in patients with burns ≥ 20% TBSA. Methods: Based on the ABRUPT trial, inclusion was increased to ≥ 25% TBSA a