LIPID-BASED DRUG DELIVERY SYSTEMS FOR POORLY WATER-SOLUBLE DRUGS: A REVIEW

Poor water solubility is still one of the toughest problems in drug development today. It really limits how effective a lot of new drugs can be. Around 40–70% of new chemical compounds just don’t dissolve well in water. So, when you take them by mouth, they don’t break down enough in your gut, which means people absorb less of the drug, and the results can be unpredictable. This issue is especially tough for drugs in Biopharmaceutics Classification System (BCS) Class II and Class IV—these are th