llluminating the live-cell dynamics of early interactions between neutrophils and the microsporidian parasite Encephalitozoon cuniculi
Eugénie Carriere·Pascale Gueirard·Juliette Gilbert·Marjolaine Vareille-Delarbre·Frédéric Delbac·Julien Verlaguet·Enzo Julien
Abstract Background Encephalitozoon cuniculi is an obligate intracellular parasite that affects birds and mammals, including humans, and belongs to the phylum Microsporidia. The innate immune system serves as the first line of defense against infection, but it only partially clears the parasite. Microsporidia are known to modulate the effector functions of phagocytes. They can survive and multiply inside macrophages (MOs) to evade destruction after phagocytosis and also modify the functional pro