Prolonged compression and abnormal stretch is the cause of many types of Peripheral Nerve Injuries (PNI), but injury due to overtightened handcuffs is a rare occurrence. These neuropathies have a poor prognosis if not treated promptly. A 24-yearold man with combined radial, median, and ulnar nerve injury following handcuff restraint received a 40-day physiotherapy protocol intervention (30-40 min/session). Interventions included proprioceptive neuromuscular facilitation, functional electrical st