Dynamic comorbidity trajectories spanning the diagnosis of depression: nationwide cohort study

Background Depression is often accompanied by multisystem comorbidities, but the time trajectories of these comorbidities remain unclear. Aims We aimed to define the temporal sequence of comorbidity accrual relative to depression diagnosis, and examine how this trajectory differs in recurrent depression. Method A total of 32 953 individuals with depression were identified in the UK Biobank cohort, including 2402 with recurrent depression. The time between diagnosis of depression or recurrent dep