Case Report: Ivarmacitinib in the treatment of refractory primary cutaneous amyloidosis

Primary cutaneous amyloidosis (PCA) is a chronic, severely pruritic dermatosis characterized by amyloid deposition in the dermis. There is currently no standardized treatment for PCA, and its clinical management remains challenging. Ivarmacitinib, a novel, highly selective oral Janus kinase 1 (JAK1) inhibitor, has demonstrated significant efficacy in modulating inflammatory and pruritic pathways in atopic dermatitis (AD), suggesting its potential utility in related conditions. We report a compel