The systemic complexity and spatiotemporal heterogeneity of cancer demand diagnostic strategies beyond single modalities. The integration of positron emission tomography/magnetic resonance imaging (PET/MRI) with liquid biopsy offers a revolutionary paradigm for a comprehensive view of tumor biology. This approach synergizes PET/MRI’s high-resolution spatial information—covering anatomical, functional, and metabolic characteristics—with the systemic, dynamic molecular data from liquid biopsy, par
