Stratified obstetric management for heterogeneous rare diseases: a precision medicine framework based on four genetic archetypes

Rapid advances in genomic sequencing increasingly expose obstetricians to complex and heterogeneous genetic information in routine clinical practice. Traditional disease-specific screening models are no longer sufficient to guide decision-making across the broad spectrum of rare disorders encountered in reproductive medicine. Frontline clinicians require a universal yet clinically intuitive framework that links the biological logic of disease to the most appropriate obstetric intervention. In th