NK cell hyperactivation drives macrophage repolarization and limits M2 bias in pemphigus vulgaris

Background Macrophages and natural killer (NK) cells are innate immune components proven to be either pathogenic, protective, or both in autoimmune disorders. Nonetheless, the function of macrophages in the pathogenesis of pemphigus vulgaris (PV), an autoimmune skin disorder, is lacking. Objectives We aimed to investigate macrophages and their crosstalk with NK cells in PV, with a particular focus on how these interactions influence their functionalities. Methods Flow cytometry and immunofluores