Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials
Fabiana V. M. Gimenez·Vitor E. Valenti·Lívia Santesso·Lívia M. A. da Silva·Lara A. Girotto·Bruno M. Candeloro·Sandra Maria Barbalho·Andrey A. Porto·Rodrigo D. Raimundo·Luiz Carlos de Abreu·Natalia Pasternak
Introduction Creatine, recognized for its regulatory functions in various metabolic tissues, has aroused interest regarding its systemic effects. This study aimed to evaluate the impact of creatine supplementation on blood lipid profile parameters. Methods A systematic review with meta-analysis was conducted following the PRISMA guidelines (CRD420251025690). Searches were conducted in EMBASE, Lilacs, CINAHL, MEDLINE/PubMed, Cochrane, Scopus, and Web of Science databases up to June 2025. Randomiz