Species-dependent susceptibility of enterococci to bovine cathelicidin BMAP-28 and its relationship to membrane fatty acid composition

Antimicrobial peptides (AMPs) are promising agents against multidrug-resistant bacteria. The bovine cathelicidin BMAP-28 is a cationic α-helical AMP with broad-spectrum activity, but its effects on enterococci and determinants of susceptibility remain unclear. Here, we compared the activity of BMAP-28 and four analogs against Enterococcus faecalis and Enterococcus faecium . E. fecium ATCC49533 and E. faecium ATCC6059 were used as reference strains. E. fecium and E. faecium isolates were obtained