Integrated metabolomics and computational analysis suggest that a Sanghuangporus vaninii-based formulation alleviates T2DM in mice and modulates hepatic morphine-3-glucuronide axis

Introduction This study aimed to investigate the therapeutic material basis and mechanisms of a Sanghuangporus vaninii -based functional food formulation (FSV) in type 2 diabetes mellitus (T2DM) using an integrated approach combining chemical profiling, metabolomics, and computational biology. Methods Chemical profiling of FSV was performed using UPLC-QTOF/MS, followed by network pharmacology to identify core bioactive constituents. The therapeutic effects of FSV were evaluated in a T2DM mouse m