Aquaculture has expanded rapidly over recent decades, positioning salmon farming as a major contributor to global food security while intensifying concern over antimicrobial use and the emergence of antimicrobial resistance (AMR). Chile, the world’s second-largest producer of farmed salmon, represents a critical case study because of its historically high dependence on antibiotics, particularly florfenicol and oxytetracycline. This dependence is driven largely by the endemic burden of salmon ric