Identification of biomarkers in diabetic neuropathy: a Mendelian randomization and bioinformatics analysis

Background This study elucidated several plasma proteins that are causally linked to the risk of diabetic neuropathy (DN), offering novel insights into the protein-mediated DN pathogenesis and potential targets for therapeutic intervention. Methods We employed Mendelian randomization (MR) utilizing genome-wide association study (GWAS) data to evaluate the causal effects of 4,907 proteins on DN. We retrieved a high-throughput sequencing dataset (GSE148061, containing 53 DN patients and 53 healthy