Obesity, Inflammation, and Tumor Microenvironment in Three-Dimensional Models of Breast Cancer
Yarely M. Salinas-Vera·César López‐Camarillo·Yussel Pérez‐Navarro·Jonathan Puente-Rivera·María Elizbeth Álvarez-Sánchez
Obesity is recognized as a risk factor for breast cancer development and progression. Adipocytes exert their oncogenic effects through complex and interconnected biological mechanisms that encompass metabolic dysfunction, chronic low-grade inflammation, and systemic endocrine alterations. Herein, we reviewed the current evidence explaining how obesity induces a state that reprograms adipose tissue and remodels the breast cancer tumor microenvironment (TME). We first discuss the systemic and loca