HAdV55 reprograms host 3D genome architecture and mitochondrial metabolism to drive pathogenesis
Kaiying Wang·Hongbin Song·Zixuan Chen·Ning Wang·Dingchen Li·Hao Hong·Xiong Liu·Yanfeng Lin·Qichao Chen·P Li·Lang Yang·Leili Jia·Haifeng Pan·Yongqiang Jiang·Jinhui Li
Human adenovirus type 55 (HAdV55), an emerging recombinant pathogen linked to severe respiratory outbreaks, exhibits heightened virulence and replication efficiency, yet its mechanisms of host interaction remain poorly resolved. Here, we integrate transcriptomic and 3D genomic analyses to define the spatiotemporal interplay between HAdV55 and A549 cells. Temporal profiling revealed triphasic host transcriptional reprogramming, with distinct clusters of genes governing cell survival, apoptosis, a