virus-based-gene-therapy-research

Nature Communications, Published online: 05 September 2026; doi:10.1038/s41467-026-77599-6 There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American bats, expanding knowledge of coronavirus diversity and features linked to zoonotic potential.

Pseudomonas aeruginosa typically carries three T6SSs, but clinical isolates can harbor an additional H4 system whose function was unknown. Wu et al. show that the H4-T6SS of clinical isolate LYSZa7 is a functional secretion apparatus when transcriptionally activated. They identify TseMt as a major antibacterial effector that acts in the periplasm, binds membranes, and forms ion-conducting pores. …

Pseudomonas aeruginosa typically carries three T6SSs, but clinical isolates can harbor an additional H4 system whose function was unknown. Wu et al. show that the H4-T6SS of clinical isolate LYSZa7 is a functional secretion apparatus when transcriptionally activated. They identify TseMt as a major antibacterial effector that acts in the periplasm, binds membranes, and forms ion-conducting pores. …

The birth of Louise Brown in 1978, the world's first baby conceived through assisted reproductive technology (ART), was a major breakthrough that reshaped the field of reproductive medicine.

Furthermore, the researchers observed that in over half of the participants, the tumors stopped growing or reduced in size for as long as three years post-treatment—including one participant whose cancer has remained to this day in complete remission. B7-H3-targeting CAR-T cell therapy could bring new hope to patients living with treatment-resistant recurrent glioblastomas who currently […]

Other archives and libraries around the world may also contain genetic traces of past disease outbreaks.

Researchers at the University of Oslo and Oslo University Hospital have, together with international collaborators, discovered that a small molecule made exclusively by gut bacteria can actively drive disease in the bile ducts and worsen primary sclerosing cholangitis (PSC), a serious liver and bile duct disease.

Gram-negative bacteria are responsible for causing several infections that are hard to treat, owing to their high resistance to antibiotics.

DUBLIN, IRELAND—According to a statement released by University College Dublin (UCD), DNA samples obtained from […] The post Sheep Pox Virus Tracked With Medieval Parchment appeared first on Archaeology Magazine .

Nature, Published online: 01 September 2026; doi:10.1038/d41586-026-02740-w Small trial targeted liver proteins that play a part in the regulation of lipid levels.

A Rutgers-led international team co-authored a study, which was published in Nature Neuroscience, revealing 36 genes significantly increasing the risk for obsessive-compulsive disorder (OCD) and chronic tic disorders. This research offers the most comprehensive biological insight into the development of these conditions and potential future treatments.

Nature Communications, Published online: 04 September 2026; doi:10.1038/s41467-026-77542-9 The study reports the emergence of a new Ebola variant in a remote area of Kasai Province, DR Congo. The findings highlight the need for rapid detection and sequencing to better identify variants and quickly respond to outbreaks.

He had been athletic and healthy. Then came years of exhaustion, pain, memory problems, and...

Longwei Liu is working to create cures that remotely trigger cell and gene therapies for conditions including cancer and a genetic disorder that can rob infants of their vision. The post USC researcher uses ultrasound, genetic engineering to develop targeted treatments for blindness and other diseases appeared first on USC .

Inherited retinal dystrophies (IRDs) represent heterogeneous genetic eye disorders frequently linked to RPE65 mutations. Voretigene neparvovec (VN, Luxturna), an AAV2-mediated gene therapy, remains the sole approved drug for biallelic RPE65-associated IRDs. This study presents 3-, 6- and 22-month follow-up findings of the first mainland Chinese patient with compound heterozygous RPE65-related Leb…

Duke researchers developed an injectable scaffold that helped stroke-damaged brains grow new blood vessels, support nerve regrowth, and recover movement in mice. The treatment appears to work partly by recruiting the body’s own immune cells, including neutrophils that may switch from damaging to helpful under the right conditions.