UBE2S promotes small cell lung cancer transformation and progression via monitoring metabolic remodeling and cell cycle

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy characterized by rapid progression and poor survival. While the ubiquitin-conjugating enzyme E2 S (UBE2S) has been investigated in non-small cell lung cancer (NSCLC), its expression, functional roles, and underlying mechanisms in SCLC remain largely undefined. This study aims to elucidate the contribution of UBE2S to SCLC pathogenesis, metabolic reprogramming, and cellular plasticity. UBE2S expression was analyzed usi