Abstract Creatinine is a cornerstone biomarker for evaluating renal function and guiding clinical decisions in chronic kidney disease, acute kidney injury, transplantation, and drug administration. However, its routine determination remains constrained by the specificity, cost, and practicality of conventional analytical methods, limiting accurate and decentralized testing, particularly at the point-of-care. Molecularly imprinted polymers (MIPs) have emerged as a robust synthetic recognition technology capable of addressing these challenges by combining molecular selectivity with high chemical stability, reusability, and design flexibility. This mini-review provides the first dedicated overview of creatinine analysis using MIPs. State-of-the-art MIP-based creatinine detection platforms are critically summarized, highlighting recent progress and general performance trends rather than technical details. Key challenges that currently limit clinical translation are briefly discussed, along with future opportunities for advancing MIP-enabled creatinine sensing toward reliable, low-cost, and portable diagnostic solutions. Overall, this review underscores the growing potential of molecular imprinting to support next-generation creatinine diagnostics, beyond traditional laboratory-based assays.