PFDN5 synergizes with anti-PD1 therapy to promote triple-negative breast cancer cell death through JAK2/STAT3/c-Myc signaling axis
Xiaoren Zhu·Min‐Bin Chen·Na Liu·Xi Wang·F Lluís Viñas·Feng Cheng·An-Qi Jin·Zhong-Peng Ge·Jianmin Wu·Jing-Jing Lu·Si-Qi Li
Triple-negative breast cancer (TNBC) shows aggressive clinical behavior and lacks targeted therapeutic options, underscoring the need for novel treatment approaches. Prefoldin subunit 5 (PFDN5), a co-chaperone involved in tumor suppression and c-Myc regulation, remains largely unstudied in TNBC. This study aims to elucidate the functional role of PFDN5 in TNBC progression and its impact on the immune microenvironment. PFDN5 expression was examined in TNBC clinical specimens and cell lines. Funct