MicroRNA-targeted reprogramming of CD8+ T cells against cancer
Yuchen Mao·Ziling Fang·Kaiyan Jing·Yiqing Shao·Kangping Yang·Jiaqiang Wu·Xianhuan Zhou·Heng Wang·Liu Y
This scoping review highlights the critical role of microRNAs (miRNAs) in mediating the bidirectional crosstalk between CD8+ T cells and tumor cells within the immunosuppressive tumor microenvironment (TME). Specific miRNAs (e.g., miR-155, miR-340-5p) orchestrate CD8+ T cell function by fine-tuning immune checkpoints (PD-1/PD-L1), metabolic reprogramming, and epigenetic states. Conversely, CD8+ T cells influence tumor behavior via exosomal miRNA transfer (e.g., miR-765). Our analysis reveals bot