The role and underlying mechanism of FABP4 dysregulation mediated by m6A modification in unexplained recurrent spontaneous abortion
Fangfang Dai·Cheng Liu·Zhimin Deng·Wei Tan·Linlin Wang·Yuwei Zhang·Hua Liu·Dongyong Yang·Xiao Yang·尹太郎·Ruiqi Wang
Unexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechanism in URSA remain unclear. FABP4 expression was analyzed in human placental tissues from URSA patients and control groups. The functional role of FABP4 was investigated using Fabp4-knockout mouse models and trophoblast cell lines. Mechanistic studies employed Seahorse me