Autoantigens play a critical role in triggering autoimmunity in autoimmune diseases. Psoriasis, a systemic autoimmune skin disease, has an incompletely defined spectrum of autoantigens in terms of both identity and function. Here, through integrated analysis of bulk transcriptomic, DNA methylomic, and immunopeptidomic datasets, we identify 10 psoriasis-associated autoantigens that are reactivated by DNA hypomethylation. Among them, transcobalamin 1 (TCN1) is a keratinocyte-secreted autoantigen t