Utility of albumin-adjusted calcium and calcium‒phosphorus difference in screening for primary hyperparathyroidism
Ataru Okumura·Hiroshi Arima·Ryosei Ashida·Mitsuhiro Kuno·玉置直樹·Toshihiro Mizuguchi·Issei Uchida·Tatsuya Bando
Primary hyperparathyroidism (PHPT) is often asymptomatic but increases the risk of osteoporosis, fractures, and cardiovascular mortality. We evaluated the effectiveness of albumin-adjusted calcium (aCa) formulas and the calcium–phosphorus (Ca–P) difference as prescreening tools for PHPT in health checkup populations. We analyzed 5550 corresponding measurements of total calcium (tCa), serum albumin (Alb), and ionized calcium (iCa) to evaluate the consistency between iCa and tCa and between iCa an