Microbial spectrum, co-detection patterns, and clinical correlations in 10,153 hospitalized children with acute respiratory infections: a large-scale tNGS analysis
Chunyun Fu·Jie Tan·Xuehua Hu·Ya Huang·Jiangyang Zhao·Guangbing Liu·Lishai Mo·Jielin Chen·Wenting Tang·Yili Zhang·Qiang Huang·Yanhua Feng·Yanqing Tang·Jiaqi Wen·Ruting Chen·Cuihong Lu·Renye Yao·Shangjuan Zeng·Xiangjun Lu·She Liang·Yan Chen·Jialing Ruan·Ning Zhu·Ziyin Huang·Shang Yi·Hao Wei·Huiping Huang·Xiaoying Chen·Qifei Li·Junming Lu
This large-scale study uncovers complex co-detection patterns and microbe-dependent outcomes in ARI. A novel bidirectional severity pattern and distinct ICU microbial profiles with robust predictive factors have been identified, aiding early risk stratification and tailored management.