Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology
Natasha E. Wade·Susan F. Tapert·Alexander L. Wallace·Rachel Visontay·Veronica Szpak·Krista M. Lisdahl·Marilyn A. Huestis·Priscila Dib Gonçalves·Hollie Byrne·L. Mewton·Joanna Jacobus·Ryan M. Sullivan
Abstract Adolescents experience extensive neurocognitive development, with cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal Adolescent Brain Cognitive Development (ABCD) Study dataset, combining self-reported substance use wit