JAK2 and NOTCH2 in gastric cancer – NOTCH2 is an independent prognosticator of poor patient outcome

Abstract Gastric carcinomas occasionally harbor genetic alterations of JAK2 and NOTCH2 . In this study we investigated the tumor biological significance of JAK2 and NOTCH2 in gastric carcinoma. The expression of JAK2 and NOTCH2 was studied by immunohistochemistry using whole mount tissue sections obtained from 447 resection specimens of gastric adenocarcinomas. A Histoscore was generated and expression data were correlated with patient survival and clinicopathological patient characteristics. Bo