Place preference in a female adolescent rat model of neuropathic pain: The effects of cannabidiol and oxycodone on cerebellum cell density
C. H. Li·Richelle Mychasiuk·Elaina Vlassopoulos·Marissa Sgro·Sydney Harris·Luke A. Henderson·Kevin A. Keay·Samantha Warren
Pain reflects an integration of sensation, cognition, and affect, whereas chronic pain is associated with maladaptation. The cerebellum is increasingly recognised as a contributor to pain, especially towards affective-motivational facets, including relief-seeking from aversive experiences. Few have specifically investigated this, and much less in females, despite the notable prevalence of chronic pain in this population. To examine preference to seek cannabidiol- or oxycodone-analgesia, and cell