Astrocytes in neuroinflammation and brain cancer

Astrocytes are increasingly recognized as active regulators of glioma progression rather than passive bystanders. In addition to blood-brain barrier support, metabolic homeostasis, and synaptic regulation, astrocytes undergo state transitions in response to tumor-derived cues, immune inflammation, and therapy-induced stress. We synthesize evidence from single-cell and single-nucleus transcriptomics, spatial transcriptomics, proteomics, and multiplex imaging to delineate major tumor-associated as