Bioactive Natural Compounds in Triple-Negative Breast Cancer: Molecular Targets and Therapeutic Perspectives
Emilia Jiménez-Flores·Daniel Simancas-Racines·Jenny Carola Cárdenas Carrera·Dolores Jima Gavilanes·Raquel Horowitz·Claudia Reytor-González·Gabriele Davide Bigoni Ordóñez·César Carrillo
Triple-negative breast cancer represents one of the most aggressive and therapeutically challenging subtypes of breast malignancies, characterized by marked biological heterogeneity, rapid progression, and limited targeted treatment options. Conventional therapies are frequently constrained by drug resistance, systemic toxicity, and high rates of recurrence. In this context, natural products have gained increasing attention as multifunctional agents capable of modulating several hallmarks of tri