Selective Induction of Cancer Cell Pyroptosis by Erbium Nanotuner Enhances Potent Anti‐Cancer Immunity

Pyroptosis, an immunogenic programmed cell death, is a robust way to activate anti-cancer immunity. However, it is very challenging to induce pyroptosis in cancer cells while sparing normal cells selectively. Herein, an Er³⁺-containing nanoparticle is screened from the whole series of lanthanides for boosting pancreatic cancer immunotherapy by selectively inducing cancer cell pyroptosis. To elicit tumor-specific inflammatory cell death, a tumor-targeting nanoplatform, termed the Erbiu