L-Arginine as an Adjuvant Chemosensitizer: Enhancement of Intestinal Permeability and Cytotoxic Activity of Doxorubicin
Ghada Saad·Amal A. Sultan·Hanin B. Alanazi·Farah B. Aldahmashi·Aryam M. Alahmary·Shouq Khalid Almutairi·Fatima Alshammari·Ghadah T. Alshammari·Afnan J. Alrashidi·Norah K. Aldousari·Haifa F. Alsubiei·Huda Owaid Hudmul AlAnazi·Meaad H. Aldossary·Rana M. Alquwayi
Background/Objectives: Doxorubicin is an anthracycline chemotherapeutic agent widely used in the treatment of breast cancer. However, its clinical utility is limited by the drug’s resistance development, low oral bioavailability, and dose-dependent side effects. The semi-essential amino acid, L-arginine, has gained attention as a potential adjuvant that could improve the drug distribution and cytotoxic effectiveness of chemotherapeutics. This study aimed to explore the multifunctional effect of