Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification
Huikang Lin·Aibo Wu Wu·Binhe Chang·Fei Sun·Yingzhu Tan·Ye Tian·Yingying Fan·Jiang Liang·Bingxuan Jia
Alternariol (AOH), alternariol monomethyl ether (AME), and tenuazonic acid (TeA) are three major emerging <i>Alternaria</i> toxins in food. In this lncRNA-mRNA omics-based study, we first decrypt the blueprint: how emerging <i>Alternaria</i> toxins induce hepatic stellate cell LX-2 transdifferentiation for liver fibrosis. AOH and AME caused the fibrotic marker α-smooth muscle actin, extracellular matrix collagen expression, and cell contraction, while TeA had no significant effect. Mechanistical