Pharmacokinetics and Dose Optimization of Ethambutol in Children on First-line Antituberculosis Therapy: An Individual Patient Data Meta-Analysis
Tae Kyu Chung·Radojka M Savic·Maureen Shin·Xuyu Zhou·Miri Yoon·Dong-Jo Yang·Samer Mouksassi·Agathe Béranger·Adrie Bekker·Navarat Panjasawatwong·Belén P. Solans·Sejung Hwang·Dvijen C. Purohit·Awewura Kwara·Eunsol Yang
Our IPDMA supports the revision of current pediatric EMB dosing guidelines for the treatment of tuberculosis. Our findings aim to ensure adequate drug exposure across all pediatric weight bands, while also accounting for toxicity and challenges related to formulation implementation and adherence.